BSRT Graduate School

Project 11

Polytrauma and Bone Regeneration

 
Track: 
Biology track
Supervisor 1: 
Serafeim Tsitsilonis
Supervisor 2: 
Matthias Pumberger
Supervisor 3: 
Jessika Appelt

 

Our young and multidisciplinary group “Molecular Traumatology” investigates the molecular and cellular bases of clinically relevant questions in musculoskeletal surgery. We are looking for an outstanding and highly motivated student (master degree in life sciences) with a strong interest in translational medicine, who will investigate bone regeneration in the event of polytrauma.

 

The combination of TBI and long bone fracture paradoxically leads to an increased callus formation in clinical settings whereby the increased callus indicates accelerated bone healing. Our group investigated this phenomenon and to further enlighten the role of polytrauma on bone healing would be the aim of this doctoral project. The gained knowledge can be used to develop new therapies to treat bone defects, which treatment up to now still represents a major therapeutic challenge in the area of musculoskeletal surgery.

 

Therefore, the candidate would work with polytrauma animal models, standard molecular (qRT-PCR, Western Blot) and histological techniques, primary cells, Flow Cytometry and ELISA.

 

References

 

1. Tsitsilonis S, Seemann R, Misch M, Wichlas F, Haas NP, Schmidt-Bleek K, Kleber C, Schaser KD. The effect of traumatic brain injury on bone healing: an experimental study in a novel in vivo animal model. Injury. 2015. 46: 661-5.

 

2. Locher RJ, Lünnemann T, Garbe A, Schaser K, Schmidt-Bleek K, Duda GN, Tsitsilonis S. Traumatic brain injury and bone healing: radiographic and biomechanical analyses of bone formation and stability in a combined murine trauma model. J Musculoskelet Neuronal Interact. 2015. 15: 309-15.