BSRT Graduate School

Linked in Regeneration

Linked in Regeneration04.07.2018 16:30 - 17:30IGS Auditorium
Title of Course: 
Senescence-associated reprogramming and stemness
Optional or Mandatory: 
This course is optional for doctoral researchers at the BSRT

Linked in regeneration” wants to offer young and senior scientists from Berlin to come together and discuss with internationally renowned guest speakers how to advance research into regenerative medicine and its translation into the clinics. The Lecture Series Linked in Regeneration 2018 is organized and hosted by young postdocs of the Berlin-Brandenburg School for Regenerative Therapies.



Wednesday, 4 July 2018 | 16.30 am

Speaker: Ngo Yin Fan 

(Charité - Universitätsmedizin Berlin, Molekulares Krebsforschungszentrum)

Host: Namrata Saha (BSRT PhD Student)


Senescence-associated reprogramming and stemness


Dr. Fan is a post-doctoral Fellow at Charité - Universitätsmedizin Berlin at the Molecular Cancer Research Center. Her research focusses on the novel phenomenon on acquisition of stemness in cellular senescence, the theoretical end of a cell. Her group at Charite recently published a therapy-induced senescence model in Emu-myc lymphoma coupled with genetically switchable targeting of H3K9me3 or p53 to mimic spontaneous senescence escape. They demonstrated that cells released from senescence re-entered the cell cycle with strongly enhanced Wnt-dependent clonogenic growth potential. The observation was further extended to multiple cancer entities from human cancer cell lines to primary samples of human hematological malignancies. The unexpected senescence-associated stemness features exert detrimental aggressive properties upon cell cycle escape, and is found enriched in relapse tumor.

Three interesting publications