Linked in Regeneration
|Linked in Regeneration||01.08.2018 16:30 - 17:30||IGS Auditorium|
Linked in regeneration” wants to offer young and senior scientists from Berlin to come together and discuss with internationally renowned guest speakers how to advance research into regenerative medicine and its translation into the clinics. The Lecture Series Linked in Regeneration 2018 is organized and hosted by young postdocs of the Berlin-Brandenburg School for Regenerative Therapies.
Wednesday, 1 August 2018 | 16.30 am
Speaker: Jason Burdick
(University of Pennsylvania, Department of Bioengineering, USA)
Host: Taimoor Qazi (BSRT Postdoc)
Shear-thinning and Self-Healing Hydrogels for Applications in Tissue Repair and Biofabrication
Jason Burdick is the Robert D. Bent Professor of Bioengineering at the University of Pennsylvania, where he leads the Burdick Polymeric Biomaterials Laboratory. His lab’s research focuses on the fundamental understanding and development of polymers for biomedical applications. His research group has pioneered the development of polymeric biomaterials – including electrospun fibers, injectable hydrogels, and 3D printed scaffolds – and demonstrated their effectiveness in drug delivery and tissue engineering for musculoskeletal and cardiovascular applications. In his lecture, Professor Burdick will talk about his lab’s work on the engineering of hydrogels for the repair of cardiac tissue and for biofabrication applications. Specifically, he will describe various designs of shear-thinning and self-healing hydrogels that permit direction injection into tissues or processing through extrusion-based 3D printing. For cardiac repair and functional improvements, these hydrogels may be delivered percutaneously and used to deliver therapeutics (e.g., protease inhibitors, microRNA) that alter left ventricular remodeling after myocardial infarction. To expand on materials appropriate for 3D-printing, shear-thinning hydrogels can also act as inks or as supports for the deposition of materials and cells in 3D space. Finally, the lab is developing shear-thinning granular hydrogels through the assembly of engineered microgels.
Three interesting publications
- Direct 3D Printing of Shear‐Thinning Hydrogels into Self‐Healing Hydrogels
- Injectable and Bioresponsive Hydrogels for On-demand Matrix Metalloproteinase Inhibition
- Sustained miRNA Delivery from an Injectable Hydrogel Promotes Cardiomyocyte Proliferation and Functional Regeneration after Ischaemic Injury