Linked in Regeneration
|Linked in Regeneration||13.03.2019 16:30 - 17:30||Cranach House Auditorium|
"Linked in regeneration" wants to offer young and senior scientists from Berlin to come together and discuss with internationally renowned guest speakers how to advance research into regenerative medicine and its translation into the clinics. The Lecture Series Linked in Regeneration 2018 is organized and hosted by young postdocs of the Berlin-Brandenburg School for Regenerative Therapies.
Wednesday, 13 March 2019 | 4.30 pm
Speaker: Il-Kang Na
(BIH, Charité - Universitätsmedizin Berlin)
Host: Claudia Schlundt (BSRT Postdoc)
Therapy induced immune dysregulation
As malignant tumors develop differently in every person, no two cancers are ever the same. Scientists are constantly gaining a better understanding of why this is the case, allowing them to create far more precise and personalized therapies for every patient. But how exactly does the chosen treatment method affect the tumor, the immune system, and the relationship between the two? And how can these therapies be further adapted and improved? Il-Kang Na discovered, for example, that cancer therapies can significantly impact the formation, function, and survival of the body’s own immune cells. She also successfully developed a model that allows her to observe how certain immune cells react during cell therapy. With the help of modern bioanalytical high-throughput technologies, she wants to develop a comprehensive tool that can record and monitor molecular and genetic changes at various moments during therapy. This tool would allow cancer treatment to be tailored to the individual patient and thus be significantly improved. Na wants to begin by developing a monitoring system for patients with diffuse large B-cell lymphoma – a cancer that originates from an immune cell.
Three interesting publications
- A comparative analysis of human bine marrow-resident and peripheral memory B cells
- A Transgenic Dual-Luciferase Reporter Mouse for Longitudinal and Functional Monitoring of T Cells In Vivo
- Bone marrow T-cell infiltration during acute GVHD is associated with delayed B-cell recovery and function after HSCT