BSRT Graduate School

Linked in Regeneration

Linked in Regeneration05.06.2019 16:30 - 17:30 (Wed)Cranach House Auditorium
Title of Course: 
Cell plasticity in health and disease: The Ins and Outs of the EMT
Optional or Mandatory: 
This course is optional for doctoral researchers at the BSRT

"Linked in regeneration" wants to offer young and senior scientists from Berlin to come together and discuss with internationally renowned guest speakers how to advance research into regenerative medicine and its translation into the clinics. The Lecture Series Linked in Regeneration 2018 is organized and hosted by young postdocs of the Berlin-Brandenburg School for Regenerative Therapies.



Wednesday, 5 June 2019 | 4.30 pm

Speaker: Angela Nieto

(Instituto de Neurociencias, CSIC-UMH, Alicante, Spain)

Host: Valeria Fernandez Vallone(BSRT Postdoc)



Cell plasticity in health and disease: The Ins and Outs of the EMT


As Prof. Nieto is a pioneer in the study of the epithelial to mesenchymal transition (EMT) during embryonic development and her main contribution has been the impact that the reactivation of this developmental program has in adult disease. She has shown that EMT/MET plasticity is required for migratory cancer cells to form metastases and that in non-transformed cells, the reactivation of a partial EMT is sufficient and required in fibrosis. Therefore, she opened the door to new therapeutic approaches using EMT inhibitors in anti-fibrotic therapies. Currently, their interest is focused on (i) unveiling and testing novel regulatory networks that control cell movements and plasticity, (ii) identifying protein domains/modules that convey functional evolution of cell behaviour, (iii) following cell movements during embryonic development and cancer cells from the primary tumour to the metastatic foci.

Three interesting publications