Engineering Basis for Regeneration
The BSRT is dedicated to better understanding of the internal loading conditions and kinematics that biological structures such as the musculoskeletal system have to withstand during normal daily routine, as well as during regeneration after treatment from pathological conditions or injuries. A major challenge is to accurately describe subject specific loading conditions, as well as variability, in the lower limb using state of the art engineering and IT techniques. The aim is to identify the key parameters for detecting functional deficits in order to distinguish patients that are likely to undergo normal healing and those that are more likely to exhibit delayed healing and therefore require additional treatments.
Another important aspect of the BSRT research network deals with the production of “smart” biomaterials, which can react in a defined way to external stimuli. The BSRT research network comprises projects to synthesize novel stimuli-sensitive polymeric and inorganic biomaterials for supportive structures; to form scaffolds with tailor-made properties towards the respective intended tissue engineering; to develop bio-surface engineering of the resulting scaffolds; to provide cellular engineering for applicative projects and to characterise mutual effects of interactions between biomaterials and “living” cells and tissues.
Research on biomaterial science at the BSRT concentrates primarily on understanding how mechanical or other physical properties of biological and biomimetic materials are influenced by their structure along with developing new ways of characterising their structures. The understanding of the basic mechanisms by which the structure of bone or connective tissue is optimised opens new ways for studying diseases thus enabling the development of diagnostic and treatment strategies.