Augustenburger Platz 1 13353 Berlin
Since 09/2012 PhD Student at Julius Wolff Institute, Charité - Universitätsmedizin Berlin, Germany. 07/2011 to 02/2012 Scientific Researcher in the lab of Dr. Herling, Medical Department I at Universität zu Köln, Germany. 10/2009 to 06/2010 Diploma thesis in the group of Dr. habil. Baumgrass at Deutsches Rheuma-Forschungszentrum, Berlin, Germany. 09/2006 to 01/2007 ERASMUS Semester at Université Bordeaux I, France. 10/2004 to 10/2010 Diploma in Biology at Freie Universität Berlin.
The bone and the immune system are interdependent on each other. Bone homeostasis is regulated by a well-defined interplay between osteoblasts and osteoclasts. Bone fracture healing starts with the formation of a hematoma due to the disruption of the blood vessels in the fractured area. The hematoma formation is accompanied by an inflammatory reaction. This early fracture healing phase is an indispensable step for the initiation und regulation of the regenerative healing process. T cells infiltrating the inflamed tissue play a key role in regulating this repair process by determining the local cytokine milieu. Recently, we could show that a specific depletion of CD8+ T cells improves the healing outcome. Following this strategy, a reduction of the pro-inflammatory reaction triggered by an immune cell subpopulation could be a promising approach to positively modulate the healing process. One part of my PhD project focusses on the analysis of the impact of regulatory T cells, a subpopulation of CD4+ T cells, on the bone fracture healing process as well as outcome. This will be realized in our already well-established mouse osteotomy model. After adoptive transfer of freshly isolated murine Tregs, the healing outcome will be analyzed after 21 days in comparison to an untreated wild type group. In addition, I will evaluate the healing process over 21 days in wild type mice. This evaluation includes the analysis of the spatial and temporal distribution of distinct immune cell subsets in the fractured bone as well as systemically. This will be done by histology and immunohistology as well as flow cytometry. The aim is to get a better and deeper understanding of the cell-cell and tissue-cell distribution and interaction of immune and bone cells during a normal healing situation and to determine positive effects of specific immune cell subsets on the regeneration process.
Schlundt C, Wendler S, Schell H, Volk HD, Duda GN, Schmidt-Bleek K. Inflammation and angiogenesis are interdependent systems in tissue regeneration. World Conference on Regenerative Medicine, Leipzig, 23-25 October 2013
Schlundt C, Duda GN, Könnecke I, Schell H, Volk HD, Schmidt-Bleek K. Immune cells kiss bone cells in fracture healing. 3rd Advanced Summer School: Interrogations at the Biointerface - Inflammation and Repair Interface, Porto, Portugal, 26-28 June 2013