Michael Bader

The group headed by Michael Bader at the Max Delbrück Center for Molecular Medicine (MDC) in Berlin-Buch is interested in the molecular biology and function of hormone systems involved in cardiovascular regulation, such as angiotensin, kinins, natriuretic peptides, and serotonin. The physiological functions of the genes for components of these systems are analysed by the production and analysis of transgenic and knockout mouse and rat models. Using the genetically modified animals, the pathophysiological role of the hormone systems is analyzed in cardiovascular disease models, such as myocardial infarction, and regenerative processes are assessed. Another focus of the group is the study of preimplantation embryos and the establishment and differentiation of embryonic stem cells from mice and rats with the goal to clarify the developmental role of the hormones and to allow gene-targeting technologies in the rat.