Charité Campus Virchow-Klinikum
Augustenburger Platz 1
Director of the Julius Wolff Institute, Charité - Universitätsmedizin Berlin
Since 2007 W3-Professor "Biomechanics and Biology of Bone Regeneration" and Spokesperson of the DFG Graduate School 203 "Berlin-Brandenburg School for Regenerative Therapies"
Since 2006 Vice-Director "Berlin-Brandenburg Center for Regenerative Therapies" and Deputy Chairman of the "Center for Sports Science and Sports Medicine Berlin"
For the majority of the population, injury and disease of the musculoskeletal system is a central problem. By using examples of bone and cartilage healing, we were able to demonstrate the importance of biomechanical characteristics for cells and tissues of the human musculoskeletal system. Our group aims to reproduce natural regeneration of the musculoskeletal system by identifying and targeting the most effective approaches over a number of different scales (cell, tissue, organ, extremity). In particular, the processes of inflammation, angiogenesis and woven and lamellar bone formation can all be guided through mechanical stimulation. Such knowledge can be used to optimize implants and surgical technique or to biologically stimulate the natural cascades of healing. We could demonstrate the success of such concepts by introducing new strategies into the field of orthopedic and trauma surgery. We aim to directly influence the mechanical and biological consequences in surgical treatment at different scales, from single proteins up to the level of the entire patient. Our work is based on a tight interplay between surgeons and basic researcher and thus highly ingenious and interdisciplinary. Many biotechnological aspects are unified with medical expertise in a highly coherent manner and bought into clinical practice.