Charité Campus Virchow-Klinikum
Augustenburger Platz 1
The main purpose of our research is the development and improvement of cell therapies. We are working with two cell systems: (1) T-cells to repair and support derailed immune systems by adoptive therapy. (2) The application of stem cells in various degenerative diseases. In both cases cells are recognized as the major therapeutic agent, which needs to be thoroughly characterized and if necessary functionally enhanced for therapeutic efficacy. The scope of the work thus includes improving the manufacturing modes for these cells, finding tools for the molecular and functional characterization of the cells and the studying the interaction of the cell therapeutics with the host organism in models and in patients. Specifically we are using T-cell s for the treatment of organ and cell transplantation induced adverse reactions, such as EBV or CMV virus replications. In addition, we are applying mesenchymal stem cells in therapeutic applications for neurodegeneration and cardiac disease. The selection, expansion, testing and monitoring of the cells are a major focus of the work.