Since 2010 Speaker of the Innovation Nucleus \"Polymers for Biomedicine - Berlin-Brandenburg\" (Poly4BIO BB) Since 2009 Speaker of the Cross-programme Activity \"Regenerative Medicine and Active biomaterials\", Helmholtz Association of German Research Centres Since 2008 Honorary Professor, Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin Since 2006 Vice-Director \"Berlin-Brandenburg Center for Regenerative Therapies\" and Member of the Medical Faculty, Charité – Universitätsmedizin Berlin Since 2002 Director of the Institute of Polymer Research, Helmholtz-Zentrum Geesthacht Centre for Materials and Coastal Research and Professor of Materials in Life Sciences, Faculty of Mathematics and Natural Sciences, Universität Potsdam
The Center for Biomaterial Development in Teltow as a part of Helmholtz-Zentrum Geesthacht is member of the German Helmholtz Association. In an interdisciplinary and knowledge-based design approach, polymer-based biomaterials are developed that fulfil the complex requirements for clinical applications in Regenerative Medicine. Either in the form of a (bio-)functional implant, a scaffold or a controlled factor release system (e.g. growth factors or cytokines) polymer-based materials have a great potential to stimulate or induce auto-regeneration. The work is focussed mainly on three types of polymer systems: (1) Stimuli-sensitive polymers, with the ability to realize stimuli of clinical and biological significance, (2) Polymer systems based on classical (co) monomers, aiming cell specific compatibility, biofunctionality and degradability, (3) Biomimetic polymer systems, e.g. based on peptide- and carbohydrate-polymers. Research in all stages of the complex development is performed: design and synthesis of biomaterials as well as their further processing into hollow fibres, films, particles, membranes and scaffolds from polymer solution or polymer melt. Furthermore, these materials are fully characterized and tested for cell tolerance and toxicity, as well with regard to their interaction with biological environments (in vitro and in vivo). Polymer synthesis together with shape formation, functionalization, and sterilization constitute the technology platform “biomaterial science and bioactive environments”. Multifunctionalization is obtained by physical conditioning, interface engineering and/or loading with bioactive molecules. Emphasis of medical applications according to clinical needs is on musculoskeletal (e.g. bioartificial callus for treatment of critical size bone defect), and cardiovascular area (e.g. small calibre vascular grafts) besides others. To ensure a successful transfer of research and development results into preclinical-/ clinical trials the entire development processes of biomaterial-based medical devices. Interested PhD students (chemists, biologists, physicians, engineers, veterinary medical scientists) will be able to perform their work in the field of biomaterial science in an interdisciplinary team.