Charité Campus Virchow-Klinikum
Augustenburger Platz 1
Associated Investigator at the Berlin-Brandenburg School for Regenerative Therapies
Since 2008 University Professor (W2) of Molecular Endocrinology and Deputy Director of the Institute for Experimental Endocrinology, Charité - Universitätsmedizn Berlin
Development, tissue homeostasis and regeneration are regulated by secreted signals including classical hormones, paracrine signals and nutritional metabolites. The timely and sufficient supply of macro- and micronutrients including vitamins and trace elements is pivotal for successful development, growth, tissue remodeling and regeneration. We aim to understand the interplay of nutritional factors, endocrine signals and tissue-specific pathways during these processes by experimental in vitro, mouse model and human serum analyses. One major focus of our research group is the essential trace element selenium and the selenocysteine-containing selenoproteins during these physiological processes. We have established a number of transgenic mouse models which are characterized by an impaired expression of certain selenoproteins or by an altered selenium metabolism. Respective analytical techniques to quantify the trace element status, to modify selenoprotein expression in vivo and in vitro and to study the physiological consequences have been established.