Charité Campus Virchow-Klinikum
Augustenburger Platz 1
Since 2007 Principal Investigator at the Berlin-Brandenburg Center for Regenerative Therapies
Since 2006 Consultant surgeon at German Heart Institute Berlin (DHZB) and Coordinator "RegMed@DHZB" – Initiative for Regenerative Medicine at the German Heart Institute Berlin
My research work is centered on regenerative medicine of the cardiovascular system. This includes cell therapy for myocardial regeneration and tissue engineering of cardiovascular structures. In 2001, my group was among the first to perform intramyocardial transplantation of enriched bone marrow stem cells for induction of myocardial regeneration in man. As we noticed that the regeneration capacity of autologous progenitor cells from elderly and chronically sick patients is limited, we began to evaluate the efficacy of neonatal stem cells from human umbilical cord blood in a mouse models. This experimental work has steadily progressed over several years and now encompasses the use of neonatal stem cells for tolerance induction in heart transplantation, and their “not-plasticity-related” direct anti-ischemic on cardiomyocytes. Very recent projects include the application of iPS cells for myocardial repair as well as that of RNA Aptamer technology for cardiovascular tissue engineering and cell therapy. Our clinical work with autologous cells currently includes the therapeutic application of various cell products in patients with ischemic heart disease undergoing bypass grafting and/or transmural laser revascularization, and those with end-stage heart failure who require the implantation of a mechanical assist device.